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Ovulation Induction



Clomiphene citrate acts as an anti-estrogen which increases endogenous FSH and thereby stimulates multiple follicular developments [Ref]. While its effectiveness has been described in cases of oligo-ovulation, questions have been raised regarding its usefulness in otherwise ovulatory women with unexplained infertility [Ref]. A Cochrane review summarised 14 clinical trials (1159 participants), and found no clinical benefit of clomiphene citrate in unexplained subfertility [Ref].

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