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The Unexplained Infertility Information and Support Group


Empowering you with scientific knowledge
Never lose hope!


This website was created and run by Dr Anupa Nandi, who is a Consultant Gynaecologist and Fertility Specialist working in London. She has done extensive research in the management of couples with ‘unexplained subfertility’ and was awarded an MD by the Queen Mary University, London. She is committed to working towards supporting couples with Unexplained Infertility.
This website is created with an aim to provide the most updated evidence-based information on unexplained infertility and support to anyone who has been diagnosed with Unexplained Infertility. It is a non-profit project with an aim to provide accurate and reliable information to the public.  However, it is strongly recommended that you consult with your specialist for any specific questions for your treatment.
Unexplained Infertility affects up to 30 – 40% couples with infertility.  This is a diagnosis of exclusion, made when the standard fertility investigations are unable to detect any obvious cause for infertility. It can be one of the most frustrating experiences for the couples and can have a profound impact on their physical, mental, sexual, spiritual and financial aspects of life. However, one should not lose hope. Overall success rates remain high for couples with ‘unexplained infertility’. Various things can be done to improve the chances of spontaneous conception.
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Unexplained Infertility could be due to multiple factors

The diagnosis (or no diagnosis) of unexplained infertility is made by exclusion. However, there can be various potential contributing factors responsible.



‘Unexplained infertility’ is a diagnosis of exclusion.

However, even the most sophisticated tests can fail to detect the subtle causes of subfertility.




Overall success remains high for couples with Unexplained Infertility.

Since it could be due to multiple factors, an individualised approach to diagnosis and treatment is needed. 

Expectant management

Chances of spontaneous conception remain high in couples with unexplained infertility

Ovulation induction

Women with unexplained infertility are naturally ovulating by themselves. Hence the usefulness of ovulation induction remains doubtful. 

Intra Uterine Insemination

IUI with or without controlled ovarian hyperstimulation is widely used in cases of unexplained infertility before resorting to more invasive options like IVF. 


With advances in the assisted reproductive techniques, IVF has emerged as a safe and successful treatment option.

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